Explore the complexity of the MSC-derived secretome.
Neo Eterna Advanced Acellular Regenerative Science
Neo Eterna is an acellular biologic derived from Wharton's Jelly mesenchymal stromal cells (MSCs). Its composition includes extracellular vesicles, cytokines, growth factors, RNA-associated components, and other biologically active molecules involved in cellular communication.
Beyond the Cell
The Science of the Secretome
Rather than administering living MSCs, Neo Eterna is built around the MSC-derived secretome — the complex mixture of molecules that mesenchymal stromal cells release as part of their natural communication with surrounding cells.
Exosomes & extracellular vesicles
Membrane-bound particles involved in cell-to-cell communication.
Cytokines
Signaling proteins that participate in cellular messaging.
Growth factors
Proteins studied for their roles in cellular signaling pathways.
RNA-associated components
Including RNA species carried within vesicles.
Proteins & peptides
A diverse range of biologically active molecules.
ECM-associated molecules
Components associated with the extracellular matrix.
Source
Sourced From Wharton's Jelly
Neo Eterna is derived from mesenchymal stromal cells sourced from Wharton's Jelly, the gelatinous connective tissue of the umbilical cord. According to the manufacturer, source tissue comes from screened donors and undergoes proprietary selection and processing.
The finished product is provided in an acellular format — it does not contain living cells.
Characterization
Molecular Characterization
The manufacturer reports more than 2,400 identified proteins, peptides, cytokines and growth factors in its characterization of the secretome.
The source MSCs are characterized by the manufacturer as positive for CD73, CD90 and CD105 and negative for CD34 and CD45. These markers describe the source cells used in manufacturing; they do not indicate that viable MSCs are present in the acellular final product.
Manufacturer-reported
8.5 Million+ MSC-Equivalent Bioactive Components
According to manufacturer documentation, each 1 mL of Neo Eterna contains bioactive components described as equivalent to those associated with more than 8.5 million mesenchymal stromal cells, in an acellular formulation.
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Source MSCs (characterization)
CD73+ · CD90+ · CD105+ · CD34− · CD45−
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Secretome (manufacturer-reported)
2,400+ identified proteins, peptides, cytokines and growth factors
- 03
Final product format
Acellular — no viable cells
Research
Research and Scientific Exploration
The MSC-derived secretome is an active area of preliminary scientific research. Ongoing studies explore how its components participate in cellular communication. This research is early-stage, and no clinical outcomes are established or implied.
Configurations
Available Configurations
Neo Eterna is offered in three vial volumes.
1 cc
1 mL
2 cc
2 mL
3 cc
3 mL
Volume configurations only. Exosome counts, MSC-equivalent values, concentrations and dosing are not specified for each volume. The manufacturer-reported statement of more than 8.5 million MSC-equivalent bioactive components refers to each 1 mL and is not extended to the other volumes.
FAQ
Frequently asked questions
What is Neo Eterna?
Neo Eterna is an acellular product derived from Wharton's Jelly mesenchymal stromal cells (MSCs). Manufacturer-described composition includes extracellular vesicles, cytokines, growth factors and other bioactive components.
How is Neo Eterna different from traditional stem cell products?
Neo Eterna focuses on MSC-derived bioactive components rather than living stem cells. Acellular means it does not contain viable MSCs.
What does the 8.5 million MSC-equivalent figure mean?
According to manufacturer documentation, each 1 mL contains bioactive components described as equivalent to those associated with more than 8.5 million MSCs. This does not mean the finished product contains 8.5 million living cells. The method for establishing equivalence has not been independently verified by JJV Bio.
Why is Wharton's Jelly used?
Wharton's Jelly is umbilical cord connective tissue and a recognized source of MSCs. These cells and their secreted components are studied for their roles in cellular signaling and tissue biology.
What scientific testing supports Neo Eterna?
Manufacturer materials describe molecular characterization, proteomic analysis and microbiological testing. Available Neo Eterna-specific documentation can be discussed during a consultation.
Is Neo Eterna FDA-approved?
No. No FDA approval or authorization for clinical use has been established by the materials reviewed. FDA facility registration does not constitute product approval. (Regulatory classification is addressed separately below.)
How can healthcare professionals learn more?
Schedule a consultation with JJV Bio to discuss the technology, manufacturer documentation, available research and product information.
What third-party testing has been conducted on Neo Eterna?
Manufacturer documentation references independent laboratory testing, including molecular characterization and proteomic analysis. Some reports evaluate multiple products within the manufacturer's portfolio. JJV Bio distinguishes Neo Eterna-specific findings from broader portfolio data and can discuss available supporting documentation for professional review.
What is Neo Eterna's FDA regulatory status (classification)?
The manufacturer references Section 361 of the Public Health Service Act and FDA facility registration. However, FDA registration does not constitute product approval, and registration alone does not establish that a product qualifies for regulation solely under Section 361. Product-specific regulatory classification and compliance require independent substantiation. JJV Bio does not represent Neo Eterna as FDA-approved or authorized for clinical use.
Explore Neo Eterna With JJV Bio
Schedule a conversation to review the science, manufacturer documentation and partnership considerations.
For Healthcare Professional Education. Information about Neo Eterna is provided for scientific and educational purposes only. The product and referenced research have not been established as safe or effective for treating any disease or medical condition. No FDA approval or authorization for clinical use is implied.
Regulatory note. Products in this portfolio do not share a single regulatory status, and some are not FDA-approved or cleared. Product-specific regulatory information must be reviewed before any marketing use. Nothing on this site is a claim of safety, efficacy, or suitability for any indication.